Suppressing aging and extending longevity: Will the twain meet?
Judith Campisi, Buck Institute for Research on Aging and Lawrence Berkeley National Laboratory
Summary: Average human lifespan has increased remarkably in the last century and continues to rise, albeit more slowly. Much of this rise is due to medical advances that postpone, treat or prevent certain age-related pathologies. Nonetheless, many older people face years of disability, with enormous human and economic costs. What are the prospects for human health spans and longevity? Recent advances in aging research have identified a few basic mechanisms that appear to drive aging in complex organisms, including humans. Judith Campisi from the Buck Institute of Age Research in Berkeley will discuss one of these mechanisms -- a multifaceted stress response -- and the prospects for interventions that have the potential to extend the years of healthy life by manipulating this response. She will also discuss the much-debated prospect of extending longevity or absolute years of life.
About the speaker
Judith Campisi received a PhD in Biochemistry from the State University of New York at Stony Brook, and postdoctoral training in cell cycle regulation at the Dana-Farber Cancer Institute and Harvard Medical School. As an Assistant Professor at the Boston University Medical School, she studied the role of cellular senescence in suppressing cancer, and soon became convinced that senescent cells also contributed to aging. She left Boston University as an Associate Professor to become a Senior Scientist at the Lawrence Berkeley National Laboratory in 1991. In 2002, she started a second laboratory at the Buck Institute for Age Research, where she is a Professor. At both institutions, Campisi established a broad program to understand the relationship between aging and age-related disease, with an emphasis on the interface between cancer and aging. Her laboratory made several pioneering discoveries in these areas, and her research continues to challenge and alter existing paradigms.
In recognition of her research and leadership, Campisi received numerous awards, including two MERIT awards from the National Institute on Aging, awards from the AlliedSignal Corporation, Gerontological Society of America and American Federation for Aging Research, the Longevity prize from the IPSEN Foundation, Bennett Cohen award from the University of Michigan, Schober award from Halle University and the first international Olav Thon Foundation prize. She is an elected a fellow of the American Association for the Advancement of Science, and serves on numerous national and international editorial and scientific advisory boards. n use the nuclear waste as fuel obviate those concerns.